East River BioSolutions’ proprietary TissueSpec® technology enables the isolation of intact native extracellular matrix (ECM) directly from natural organs.

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  • What is TissueSpec® matrix?

    TissueSpec® matrix is a series of native extracellular matrix (ECM) products derived from a variety of natural organs and optimized for ease of use in research. Extracellular matrix is isolated directly from natural organs like bone, heart, liver, and lung and processed into multiple TissueSpec® matrix formats for use in cell and tissue culture studies.

  • What are the advantages of culturing my cells with TissueSpec® matrix instead of other substrates or tumor basement membrane extracts?

    TissueSpec® matrix products provide your cells a host of native, bioactive micro-environmental factors not present in other cell culture substrates. Unlike tumor basement membrane extracts, TissueSpec® matrix products do not contain any exogenous growth factors.

  • What is the source of organs used to derive TissueSpec® matrix products?

    TissueSpec® matrix products are derived from natural organs of porcine origin. East River BioSolutions also offers custom matrix products derived from alternative sources (e.g., bovine).

  • What's the difference between TissueSpec® matrix scaffolds and sponges?

    TissueSpec® matrix scaffolds are acellular tissue sections that retain the matrix architecture and ultrastructural properties of the original tissue. TissueSpec® matrix sponges are processed in order to homogenize matrix architecture, topography, and other biophysical properties.

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NativeCoat™ ECM Surface Coating
TissueSpec® ECM Hydrogel
TissueSpec® ECM Hydrogel
TissueSpec® ECM Hydrogel


“We were looking for a cartilaginous extracellular matrix scaffold to use for engineering cartilage tissue. East River BioSolutions offered the ideal solution with their hyaline cartilage-derived matrix hydrogel system, a product we could use to encapsulate chondrocytes within the three-dimensional tissue environment the cells are exposed to in native cartilage. The East River BioSolutions scaffolds came in three ready-to-use tubes that readily mix with cell suspension media and gel quickly. Chondrocytes grow really well in the hydrogels, and these tissue constructs have developed mechanical and biochemical properties and histological staining similar to native articular cartilage.”

-Bob Nims, PhD, Columbia University